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IVF Breast Cancer

Recent Peer-Reviewed Studies

June 2011 University of Ljubljana Study in Journal of Gynecologic Oncology
Clearly written study with 825 cases and 732 controls in study. Results indicate women with snps on 2 estrogen metabolism genes face 2 fold risk of breast cancer. Women with snps on 3 estrogen metabol
CYP1B1, COMT, GST and MnSOD genes togeth[…]
Adobe Acrobat document [308.6 KB]
May 2011 Study American Association of Cancer Research from Vanderbilt University, Fischer-Bosch Institute Stutgart and University Tubingen
Large Study with 1143 Breast cancer patients and 1155 controls with further examination of the Nashville Breast Cohort study of 16,946 women. Results indicate 1.88 fold increase of breast cancer risk
Cancer BioMarkers May 2011 American Asso[…]
Adobe Acrobat document [670.3 KB]
Vanderbilt University, Nashville, TN, 2009 NY Academy of Sciences
Estrogen Metabolism and Breast Cancer: A Risk Model
Steroid Enzymes and Cancer: 2009 New York Academy of Sciences
Comment from Babs: If you can only read one item, read this study.
More Studies on Estrogen Metabolism SNPs and Breast Cancer below.
F. Parl NYAS – Breast Cancer and Metabol[…]
Adobe Acrobat document [273.2 KB]
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK,
June 2012 Journal of the National Cancer Institute
CYP3A variation, Premenopausal Estrone Levels and Breast Cancer Risk

Fertility Curve Shifts Down 5 Years

University of St. Andrews and University of Edinburgh, Scotland, U.K. Human Ovarian Reserve from Conception to Menopause – 2010
This study demonstrates that for 95% of women by the age of 30 only 12% of their ovarian reserves remain. By age 40, 3% remains.
Human Ovarian Reserves 2010.pdf
Adobe Acrobat document [688.0 KB]

Fertility Drugs and Breast Cancer Studies


Fertility Drug Usage and Cancer Risk, Journal of the National Cancer Institute, July 2012

This study has been widely publicized as one which indicated increased risk between Fertility Medications and Cancer but the study is very flawed. Only summary is available which I have included.

7.2012 _Fertility Drug Use and Cancer Risk

Danish Cancer Society, Institute of Cancer Epidemology & Juliane Marie Center, Copenhagen, Denmark — Breast Cancer Risk after Fertility Drugs Exposure
Cancer Epidemiology, Biomarkers and Prevention July 2007 16: 1400
Breast Cancer Risk after Fertility Drugs[…]
Adobe Acrobat document [101.5 KB]
John Hopkins, Bloomberg School of Public Health, Washington, D.C. Cancer Risk after Ovulation Induction
American Journal of Epidemiology, Vol. 169, No 3 November 2008
“In conclusion, the present study demonstrated an association between treatment for ovulation induction and overal risk of cancer, partic
Cancer Risk after Treatments for Ovulati[…]
Adobe Acrobat document [109.4 KB]

Hormone Replacement Therapy and Breast Cancer Studies

INSERM, IARG WHO, Univerity of Paris Sud —- Breast Cancer Risk & Hormone Replacement Therapy
International Union Against Cancer, 2004
Adobe Acrobat document [630.6 KB]
INSERM, University of Paris & Instituto Nazionale Tumori, Milan — Different Postmenopausal Hormone Therapies & Risk of Breast Cancer
Journal of Clinical Oncology, March 2008
Adobe Acrobat document [355.4 KB]

Studies on Estrogen Metabolism SNPs and Breast Cancer

University of Nebraska Medical Center, Eppley Institute, Nashville, TN, Center for Human Genetics — Depurinating estrogen-DNA adducts in the etiology and prevention of breast and human cancer
Future Oncology, 2010
fut onc 6 75 2010 depurinating estrogen-[…]
Adobe Acrobat document [718.4 KB]
Vanderbilt University, Nashville, TN, Center for Human Genetics — Estrogen, Enzyme Variants and Breast Cancer Risk Model
Cancer Epidemiol Biomarkers Prev 2006;15(9).
“….The model identified a subset of women with an increased risk of breast cancer based on their enzyme halotype and consequent E2-3, 4-Q production.”
Estrogen, Enzyme Variants and Breast Can[…]
Adobe Acrobat document [326.2 KB]
University of Nebraska Medical Center, Eppley Institute, Nashville TN, Center for Human Genetics — Relative Imbalances in Estrogen Metabolism and conjugation in breast tissue…biomarkers
Carcinogenesis, 2003
12727798 Rogan.pdf
Adobe Acrobat document [156.8 KB]
Vanderbilt University, Nashville, TN — Multifactor-Dimensionality Reduction Reveals High Order Interactions among….
“Estrogen Metabolism Genes in Sporadic Breast Cancer” American Society of Human Genetics, 2001. Babs comment: “This is first study on human tissue correlating these SNPs and Breast Cancer.”
Multifactor Dimensionality.pdf
Adobe Acrobat document [520.4 KB]
Ningxia Medcal, Yinchuan, Ningxia, P.R. China & Lancaster University, Lancaster, UK — CYP1B1 Polymorphisms and Breast Cancer
Biomarkers Insight 2010:5
“Our results suggest that certain polymorphisms in the CYP1B1 gene might increase risk for breast cancer among Han Chinese, perhaps because they influence the efficiency of C
CYP1B1-Polymorphisms- and Breast-Cancer.[…]
Adobe Acrobat document [1’000.0 KB]
University of Nebraska, Eppley Institue for Cancer Research — Breast Cancer and Estrogen Metabolism: Catechol estrogen quinones as initiators of breast cancer
Biochim Biophys Acta 2006 Aug:1766
“In summary, this evidence strongly indicates that estrogens can become endogenous tumor initiators when CE3-3, 4-Q react with DNA to form specific depurinating addu
Breast Cancer and Estrogen Metabolism.pd[…]
Adobe Acrobat document [25.2 KB]
Harvard School of Public Health & Brigham Women’s Hospital & Harvard Medical School —-CYP1B1 SNPs and Breast Cancer Risk
Cancer Epidemiology, Biomarkers and Prevention, Vol 11, May 2002
“Our results suggest that despite a potential association with estradiol levels, neither the V432L nor the A453S polymorphisms in the C
CYP1B1 SNPs and Breast Cancer Risk.pdf
Adobe Acrobat document [32.6 KB]
CYP1B1 and COMT SNPS and Breast Cancer in Turkish Women
Archives of Toxicology Vol 76, Num 11/November 2002
“We conclude that the CYP1B1*3 allele appears to be a factor for susceptability to breast cancer in Turkish women…”
CYP1B1 and COMT SNPS and Breast Cancer i[…]
Adobe Acrobat document [25.9 KB]
National Taiwan University, Taipei, Taiwan Breast Cancer Risk and SNPs CYP17, CYP1A1 and COMT
Cancer Research 59, October 1999.
Breast Cancer Risk and SNPs CYP17, CYP1A[…]
Adobe Acrobat document [438.2 KB]

Estrogen Metabolism & Breast Cancer Risk:

An impaired estrogen metabolism (SNPs on the Genes CYP1B1, CYP1A1, COMT, GSTM or GSTP1) + exogenous estrogens (fertility treatments, long term HRT) will lead to an over expression of the carciogenic estrogens.

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